TNFRSF14, TNF receptor superfamily member 14, 8764

N. diseases: 100; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.200 Biomarker disease RGD Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure. 18353719 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 AlteredExpression disease LHGDN High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases. 14749527 2003
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.100 Biomarker group LHGDN Involvement of HVEM receptor in activation of nuclear factor kappaB by herpes simplex virus 1 glycoprotein D. 18671825 2008
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.100 Biomarker group LHGDN Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA. 11976496 2002
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.100 Biomarker group LHGDN Herpes simplex virus (HSV) entry requires the interaction of glycoprotein D (gD) with a cellular receptor such as herpesvirus entry mediator (HVEM or HveA) or nectin-1 (HveC). 12915568 2003
CUI: C0004096
Disease: Asthma
Asthma 		0.020 AlteredExpression disease LHGDN High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases. 14749527 2003
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.020 AlteredExpression disease LHGDN High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases. 14749527 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease LHGDN Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis. 11742858 2001
CUI: C3714514
Disease: Infection
Infection 		0.010 Biomarker group LHGDN Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. 15110526 2004
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.110 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.110 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0008313
Disease: Cholangitis, Sclerosing
Cholangitis, Sclerosing 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular 		0.370 CausalMutation disease CGI
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 Biomarker disease CTD_human Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842 2010
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.300 Biomarker disease CTD_human Multiple common variants for celiac disease influencing immune gene expression. 20190752 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 GeneticVariation disease BEFREE However, we did not find significant association between neither BANK1 rs3733197 polymorphism nor MMEL1/TNFRSF14 rs3890745 polymorphism and RA. 28925718 2017
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 GeneticVariation disease BEFREE TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis. 20962851 2011
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 GeneticVariation disease BEFREE A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA. 22365150 2012
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 Biomarker disease BEFREE To study the expression of LIGHT (tumor necrosis factor superfamily 14) and herpesvirus entry mediator (HVEM; tumor necrosis factor receptor superfamily 14) in rheumatoid arthritis (RA) and to determine the regulatory role of LIGHT on the effector functions of fibroblast-like synoviocytes (FLS). 17393389 2007
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 GeneticVariation disease BEFREE The aim of this study was to investigate the combined effect of the TNFRSF14 rs6684865 and TNFRSF6B rs4809330 polymorphisms in RA predisposition. 20187130 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.380 Biomarker disease BEFREE Herpesvirus entry mediator-Ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model. 19234211 2009